Sulfamethoxazole vs Septra ds - from FDA reports

This is a side effect comparison of Sulfamethoxazole and Septra ds. The study is created by eHealthMe based on reports from FDA, and is updated regularly.

How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood.

On Feb, 11, 2019

82,081 people who take Sulfamethoxazole and Septra ds are studied.

Number of reports submitted per year:

Sulfamethoxazole vs Septra ds drug comparison reports.

Drugs in this study:

  • Septra Ds (sulfamethoxazole; trimethoprim)
  • Sulfamethoxazole (sulfamethoxazole)

eHealthMe real world results:

Most common side effects:

  1. Pyrexia (fever)
  2. Nausea (feeling of having an urge to vomit)
  3. Diarrhoea
  4. Vomiting
  5. Dyspnoea (difficult or laboured respiration)
  6. Anaemia (lack of blood)
  7. Fatigue (feeling of tiredness)
  8. Pneumonia
  9. Pain
  10. Headache (pain in head)
Septra Ds:
  1. Pyrexia (fever)
  2. Nausea (feeling of having an urge to vomit)
  3. Pain
  4. Pneumonia
  5. Vomiting
  6. Diarrhoea
  7. Anaemia (lack of blood)
  8. Dyspnoea (difficult or laboured respiration)
  9. Anxiety
  10. Fatigue (feeling of tiredness)

Most common side effects experienced by people in long term use:

  1. Nausea (feeling of having an urge to vomit)
  2. Vomiting
  3. Anaemia (lack of blood)
  4. Diarrhoea
  5. Pyrexia (fever)
  6. Dehydration (dryness resulting from the removal of water)
  7. Dizziness
  8. Renal Failure Acute (rapid kidney dysfunction)
  9. Hyperlipidaemia (presence of excess lipids in the blood)
  10. Gamma-Glutamyltransferase Increased
Septra Ds:
  1. Abortion Spontaneous (naturally occurring miscarriage)
  2. Pyrexia (fever)
  3. Pneumonia
  4. Blood Lactate Dehydrogenase Increased
  5. Febrile Neutropenia (fever with reduced white blood cells)
  6. Depression
  7. Retinitis (inflammation of the retina in the eye)
  8. Pulmonary Oedema (fluid accumulation in the lungs)
  9. Dyspnoea (difficult or laboured respiration)
  10. Cytomegalovirus Viraemia (cytomegalo virus in blood stream)

What are the drugs?

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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