Retin-a vs. Zinc sulfate


We compare the side effects and drug effectiveness of Retin-a and Zinc sulfate. The study is created by eHealthMe based on reports of 9,764 people who take Retin-a and Zinc sulfate, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers. Choose a tool to use eHealthMe.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How the study uses the data?

The study is based on tretinoin and zinc sulfate (the active ingredients of Retin-a and Zinc sulfate, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered.

What is Retin-a?

Retin-a has active ingredients of tretinoin. It is often used in acne. Check the latest outcomes from 1,665 Retin-a users, or browse all drugs.

What is Zinc sulfate?

Zinc sulfate has active ingredients of zinc sulfate. It is often used in acne. Check the latest outcomes from 1,644 Zinc sulfate users, or browse all drugs.

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

Data + Experience to manage medications:

On eHealthMe, we believe health data should work with individual experience to improve drug outcomes. With our Ginger Health app, you can get one-to-one mobile support from people like you. Patients and caregivers can get paid with their health care experience as a Care Guide. Learn more about Care Guides.

On Mar, 18, 2019

9,764 people who take Retin-a and Zinc sulfate are studied.

Number of reports submitted per year:

Retin-a vs Zinc sulfate drug comparison reports.

Drugs in this study:

  • Zinc Sulfate (zinc sulfate)
  • Retin-A (tretinoin)

Most common side effects:

  1. Drug Ineffective
  2. Dyspnoea (difficult or laboured respiration)
  3. Nausea (feeling of having an urge to vomit)
  4. Pneumonia
  5. Pain
  6. Vomiting
  7. Fatigue (feeling of tiredness)
  8. Diarrhoea
  9. Pyrexia (fever)
  10. Anaemia (lack of blood)
Zinc Sulfate:
  1. Dry Skin
  2. Dermatitis Exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
  3. Rash Erythematous (redness of the skin)
  4. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  5. Pain
  6. Pyrexia (fever)
  7. Nausea (feeling of having an urge to vomit)
  8. Anxiety
  9. Depression
  10. Headache (pain in head)

Most common side effects experienced by people in long term use:

  1. Drug Ineffective
  2. Condition
  3. Tendonitis (a condition that causes pain and swelling of tendons)
  4. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  5. Melaena (the passage of black, tarry stools)
  6. Cholangitis Acute (rapid infection of bile duct)
  7. Cholangitis (infection of the bile duct)
  8. Cardiovascular Disorder (heart diseases)
  9. Pyrexia (fever)
  10. Dry Mouth
Zinc Sulfate:
  1. Dizziness
  2. Dyspnoea (difficult or laboured respiration)
  3. Nausea (feeling of having an urge to vomit)
  4. Headache (pain in head)
  5. Fatigue (feeling of tiredness)
  6. Weight Decreased
  7. Asthenia (weakness)
  8. Depression
  9. Chest Pain
  10. Diarrhoea

Drug effectiveness:

  • not at all: 9.6 %
  • somewhat: 28.0 %
  • moderate: 33.6 %
  • high: 19.2 %
  • very high: 9.6 %
Zinc Sulfate:
  • not at all: 1.9 %
  • somewhat: 30.48 %
  • moderate: 31.43 %
  • high: 23.81 %
  • very high: 12.38 %

Do you take Retin-a or Zinc sulfate?

You are not alone:

Related studies:

Mobile peer-to-peer support:

Ginger Health (developed by eHealthMe) has millions of focused support groups to join: each group for one drug side effect, symptom, drug or condition. You can also follow Care Guides who "have been there" to help you meet care goals and improve day-to-day life.

Recent publications that referenced eHealthMe studies

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.