Doxy 100 vs Loestrin 24 fe - from FDA reports

This is a side effect comparison of Doxy 100 and Loestrin 24 fe. The study is created by eHealthMe based on reports from FDA, and is updated regularly.

How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood.

On Feb, 11, 2019

39,904 people who take Doxy 100 and Loestrin 24 fe are studied.

Number of reports submitted per year:

Doxy 100 vs Loestrin 24 fe drug comparison reports.

Drugs in this study:

  • Doxy 100 (doxycycline hyclate)
  • Loestrin 24 Fe (ethinyl estradiol; norethindrone acetate)

eHealthMe real world results:

Most common side effects:

Doxy 100:
  1. Nausea (feeling of having an urge to vomit)
  2. Pain
  3. Anxiety
  4. Headache (pain in head)
  5. Drug Ineffective
  6. Fatigue (feeling of tiredness)
  7. Vomiting
  8. Breast Cancer
  9. Diarrhoea
  10. Depression
Loestrin 24 Fe:
  1. Nausea (feeling of having an urge to vomit)
  2. Pain
  3. Vomiting
  4. Dyspnoea (difficult or laboured respiration)
  5. Headache (pain in head)
  6. Anxiety
  7. Diarrhoea
  8. Fatigue (feeling of tiredness)
  9. Dizziness
  10. Pyrexia (fever)

Most common side effects experienced by people in long term use:

Doxy 100:
  1. Breast Cancer Female
  2. Breast Cancer
  3. Depression
  4. Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  5. Headache (pain in head)
  6. Pulmonary Embolism (blockage of the main artery of the lung)
  7. Pain In Extremity
  8. Anxiety
  9. Pain
  10. Abdominal Pain
Loestrin 24 Fe:
  1. Anxiety
  2. Depression
  3. Anaemia (lack of blood)
  4. Deep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  5. Suicide Attempt
  6. Pain In Extremity
  7. Aggression
  8. Oedema Peripheral (superficial swelling)
  9. Nausea (feeling of having an urge to vomit)
  10. Suicidal Ideation

What are the drugs?

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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