Aczone vs Adapalene - from FDA reports

This is a side effect comparison of Aczone and Adapalene. The study is created by eHealthMe based on reports from FDA, and is updated regularly.

How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood.

On Feb, 11, 2019

7,254 people who take Aczone and Adapalene are studied.

Number of reports submitted per year:

Aczone vs Adapalene drug comparison reports.

Drugs in this study:

  • Adapalene (adapalene)
  • Aczone (dapsone)

eHealthMe real world results:

Most common side effects:

  1. Depression
  2. Anxiety
  3. Pain
  4. Dry Skin
  5. Drug Ineffective
  6. Headache (pain in head)
  7. Dyspnoea (difficult or laboured respiration)
  8. Nausea (feeling of having an urge to vomit)
  9. Inflammatory Bowel Disease
  10. Erythema (redness of the skin)
  1. Pyrexia (fever)
  2. Anaemia (lack of blood)
  3. Nausea (feeling of having an urge to vomit)
  4. Diarrhoea
  5. Dyspnoea (difficult or laboured respiration)
  6. Fatigue (feeling of tiredness)
  7. Pneumonia
  8. Vomiting
  9. Drug Ineffective
  10. Headache (pain in head)

Most common side effects experienced by people in long term use:

  1. Anxiety
  2. Chest Pain
  3. Depression
  4. Pain
  5. Insomnia (sleeplessness)
  6. Dry Skin
  7. Cholecystitis Chronic (long lasting infection of gallbladder)
  8. Asthma
  9. Alopecia (absence of hair from areas of the body)
  10. Headache (pain in head)
  1. Bicytopenia (two parameters from the full blood count are low, the term bicytopenia can be used)
  2. Anaemia (lack of blood)
  3. Pyrexia (fever)
  4. Anxiety
  5. Diarrhoea
  6. Dehydration (dryness resulting from the removal of water)
  7. Toxoplasmosis (a parasitic disease caused by the protozoan toxoplasma gondii)
  8. Encephalopathy (functioning of the brain is affected by some agent or condition)
  9. Depression
  10. Death

What are the drugs?

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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